Targeted Orphaned Domain May Lead to Drug Therapies for Nervous System Diseases and Inflammatory Processes
Research key to possible drug therapies for nervous system diseases and inflammatory processes
"We are especially interested in the superfamily of pentameric ligand-gated ion channels (pLGICs) that includes the nAChR, GABA, 5-HT3, and glycine families," Jansen said. "The pLGICs function mainly as neurotransmitter receptors, transforming the chemical signal contained in the neurotransmitter into an electrical signal."
The current therapies make it impossible to precisely hit one target because there are more than 40 different subunits in humans. All the drugs currently in clinical use, target the extracellular or transmembrane domains, which are structurally very similar across different subunits.
Read the full story here.
Related Stories
Noise-Induced Hearing Loss in Rural Adolescents
Leigh Ann Reel, Au.D., Ph.D., CCC-A, discussed the causes and prevention strategies for noise-induced hearing loss, particularly for adolescents in rural areas.
Willed Body Memorial Service Honors Those Who Donated
On Memorial Day each May, a service is conducted at the Texas Tech University Health Sciences Center Institute of Anatomical Sciences to pay respect to the Willed Body Program donors and their families.
Molecular Pathology Preceptorship: Unmatched Value and Experience
Ericka Hendrix, PhD, MB(ASCP)CM, Program Director and Associate Professor in the Master of Science in Molecular Pathology program in the School of Health Professions spoke about the program’s preceptorship.
Recent Stories
Alumni Spotlight: Forrest Summers, MHA, BSN, R.N.
Forrest Summers, MHA, BSN, R.N., is the CEO of Perimeter Behavioral Health of Jackson.
Texas Tech University Health Sciences Center Earns SACSCOC Recognition
TTUHSC has received a clean bill of health from the regional accrediting body, the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC), following a Fifth-Year Interim Review by a committee from peer institutions.
Noise-Induced Hearing Loss in Rural Adolescents
Leigh Ann Reel, Au.D., Ph.D., CCC-A, discussed the causes and prevention strategies for noise-induced hearing loss, particularly for adolescents in rural areas.