Targeted Orphaned Domain May Lead to Drug Therapies for Nervous System Diseases and Inflammatory Processes
Research key to possible drug therapies for nervous system diseases and inflammatory processes
"We are especially interested in the superfamily of pentameric ligand-gated ion channels (pLGICs) that includes the nAChR, GABA, 5-HT3, and glycine families," Jansen said. "The pLGICs function mainly as neurotransmitter receptors, transforming the chemical signal contained in the neurotransmitter into an electrical signal."
The current therapies make it impossible to precisely hit one target because there are more than 40 different subunits in humans. All the drugs currently in clinical use, target the extracellular or transmembrane domains, which are structurally very similar across different subunits.
Read the full story here.
Related Stories
Celebrating Veterans: TTUHSC’s General Martin Clay’s Legacy of Service and Leadership
From his initial enlistment in the Army National Guard 36 years ago to his leadership in military and civilian health care management roles, Major General Martin Clay’s career has been shaped by adaptability, mission focus and service to others.
Texas Tech University Health Sciences Center School of Nursing Named Best Accelerated Bachelor of Science in Nursing Program in Texas
The TTUHSC School of Nursing Accelerated Bachelor of Science in Nursing (BSN) program has been ranked the No. 1 accelerated nursing program in Texas by RegisteredNursing.org.
TTUHSC Names New Regional Dean for the School of Nursing
Louise Rice, DNP, RN, has been named regional dean of the TTUHSC School of Nursing on the Amarillo campus.
Recent Stories
TTUHSC Cancer Researcher Honored by National Academy of Inventors
C. Patrick Reynolds, M.D., Ph.D., director of the School of Medicine Pediatric Cancer Research Center at TTUHSC, has dedicated his life as a researcher to developing treatments for childhood cancers.
TTUHSC School of Nursing Celebrates 10 Years of the Veteran to BSN Program
The TTUHSC School of Nursing recognized the 10-year anniversary of the Veteran to Bachelor of Science in Nursing (VBSN) program during the fall 2025 commencement ceremonies held Dec. 13 in Lubbock, Texas.
TTUHSC Dean to be Inducted into the National Academies of Practice as Distinguished Fellow
Gerard E. Carrino, Ph.D., MPH, dean of the TTUHSC Julia Jones Matthews School of Population and Public Health, will be inducted into the National Academies of Practice (NAP) as a Distinguished Fellow of the Public Health Academy.