Scientists Find 'Bully' Genes in Common Childhood Tumor - News Blaze

In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.

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In addition to Velculescu and Sausen, scientists involved in the research include Rebecca Leary, Sian Jones, Jian Wu, Amanda Blackford, Luis Diaz, Nickolas Papadopoulos, Bert Vogelstein, and Kenneth Kinzler from Johns Hopkins; C. Patrick Reynolds from Texas Tech University Health Sciences Center; Giovanni Parmigiani from the Dana-Farber Cancer Institute; and Michael Hogarty and Xueyuan Liu from the Childrens Hospital of Philadelphia.

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