A relatively small number of young adults develop what is called early-onset Alzheimer’s disease, which is caused by genetic mutations, but causal factors are still unknown for the vast majority of older patients who develop late-onset Alzheimer’s disease. Persons with late-onset Alzheimer’s disease have typically been diagnosed with diabetes, obesity, traumatic brain injury or an unhealthy diet before developing Alzheimer’s disease. Researchers around the world, including scientists at the Garrison Institute on Aging, note that lifestyle significantly affects the onset and progression of the disease, and that Alzheimer’s disease may be preventable — or it may be possible to delay its onset — with regular exercise and a healthy diet.
In Alzheimer’s disease, dementia typically progresses from mild, to moderate, to severe. Alzheimer’s disease patients — both early-onset and late-onset patients — eventually exhibit dementia, a term that encompasses symptoms affecting memory and thinking abilities and social inabilities that interfere with daily activities of living. In postmortem studies of brains from persons with and without the disease, researchers are identifying abnormalities in the Alzheimer’s disease brain, including the loss of synapses in nerve cells and brain tissue. In other words, the Alzheimer’s disease brain progressively shrinks, especially in the hippocampus, a brain region that is involved in long-term memory and the formation of new memories. Researchers from the Garrison institute are finding that abnormalities in Alzheimer’s disease brain cells involve reductions in energy output from mitochondria and generate adenosine triphosphate, a source of chemical energy for brain functions, such as storage of long-term memories. Garrison institute researchers are actively working to improve energy levels in brain cells by delivering mitochondria-targeted molecules to the brain.
The Garrison institute’s overall mission is to improve the quality of life in older persons through innovative and cutting edge research and the promotion of regular exercise and healthy diets. Consistent with this mission, scientists and health care professionals are investigating the impact of lifestyle and diet on mitochondria in brain cells from persons with and without Alzheimer’s disease, in order to identify how late-onset Alzheimer’s disease can be prevented or delayed, and how Alzheimer’s disease progression can be slowed. Scientists and health care professionals are involved in different approaches to achieve its mission of educating the community about how lifestyle decisions such as exercise and a healthy diet can affect Alzheimer’s disease onset and progression, how other conditions, such as diabetes and obesity, can impact Alzheimer’s disease onset, researching the identification of biomarkers designed to detect Alzheimer’s disease as early as possible in elderly individuals and researching drugs capable of targeting and delivering treatment to Alzheimer’s disease-affected.
The Garrison Institute on Aging is partnering with the Lubbock mayor’s office to support the Mayor’s Fitness Council, the mission of which is to create a healthier Lubbock by showcasing events that promote healthy lifestyles and diets. November is designated Alzheimer’s Disease Awareness Month, a perfect time to remind the community of the importance of improving exercise and diet.
While the Garrison institute scientists and health care professionals continue their valuable research, take opportunities to participate in the Mayor’s Fitness Council, educational programs and activities to stay healthy.
P. Hemachandra Reddy, Ph.D., is the executive director and chief scientific officer of Texas Tech Health Sciences Center Garrison Institute on Aging.